{"id":2479,"date":"2025-10-24T11:00:22","date_gmt":"2025-10-24T11:00:22","guid":{"rendered":"http:\/\/thetoptenwebhosts.com\/?p=2479"},"modified":"2025-10-28T13:44:16","modified_gmt":"2025-10-28T13:44:16","slug":"langone-discovery-could-develop-better-painkillers","status":"publish","type":"post","link":"http:\/\/thetoptenwebhosts.com\/index.php\/2025\/10\/24\/langone-discovery-could-develop-better-painkillers\/","title":{"rendered":"Langone discovery could develop better painkillers"},"content":{"rendered":"

\"\"<\/a><\/p>\n

NYU Langone Health researchers identified a pain receptor that could be used to <\/span>develop safer painkillers<\/span><\/a>.<\/span><\/p>\n

In the September study, a collaboration between the NYU Pain Research Center and the Department of Health Science at the University of Florence, researchers found that the pain receptor known as EP2 causes pain without inflammation. The discovery could lead to the development of alternatives to traditional painkillers like ibuprofen and naproxen, which relieve pain at the expense of disrupting the healing process.<\/span><\/p>\n

\u201cTreatment with non-steroidal anti-inflammatory drugs delays the recovery of the pathological condition,\u201d Pierangelo Geppetti, adjunct professor at the Pain Research Center and professor emeritus at the University of Florence, told WSN. \u201cSilencing the EP2 receptor in Schwann cells is able to get rid of the pain without delaying the recovery.\u201d<\/span><\/p>\n

Researchers injected test subject mice with prostaglandin E2 \u2014 a chemical that triggers EP2 pain receptors in the nervous system\u2019s Schwann cells, which are commonly related to migraines.<\/span><\/p>\n

They observed that the mice experienced inflammation without pain when pressure was applied to areas that would normally cause both effects.\u00a0\u00a0<\/span><\/p>\n

Scientists have long believed that the EP4 receptor is responsible for inflammatory pain responses, but the new study\u2019s findings could kickstart further research on the functionality of EP2. Nigel Bunnett \u2014 chair of the department of molecular pathology at the NYU College of Dentistry \u2014 told WSN that the team now aims to develop a treatment for humans, given that <\/span>current understanding of EP2 is largely based on animal testing.\u00a0<\/span><\/p>\n

\u201cIt would have to undergo safety and efficacy studies,\u201d Steve Davidson, <\/span>associate director at NYU Pain Research Center<\/span> said in an interview with WSN. \u201cBut those are a lot more likely to happen now that we understand how it works, what it binds to, and in what circumstances it\u2019s effective.\u201d<\/span><\/p>\n

Contact Zachary Karp at news@nyunews.com.<\/em><\/p>\n

This story Langone discovery could develop better painkillers<\/a> appeared first on Washington Square News<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

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